Infantile tremor syndrome in modern times

Cranial neuroimaging in infantile tremor syndrome (ITS).

Clinical, hematological and cranial neuroimaging findings of eight cases of infantile tremor syndrome are reported. All had coarse tremors, anemia, hyperpigmentation and delayed or regression of developmental milestones. Five patients had microcytic, hypochromic anemia, three had dimorphic anemia. CT scans of two cases and MRI scans of three cases showed cerebral atrophy. One of these two CT sc...

Infantile Tremor Syndrome: Still A Mystery!

With reference to the recent publication in Indian Pediatrics [1], infantile tremor syndrome may indeed be ‘down’ perhaps in terms of incidence, but certainly not ‘out’ in terms of etiology. Authors found low serum vitamin B12 only in 8 of 16 infants and they are justifiably cautious in stating that vitamin B12 deficiency is “causally associated”. There was initial worsening of tremors seen in ...

Infantile Tremor Syndrome--A Tale of 50 Years.

We continue with the second stop of our journey, the July issue of Indian Pediatrics in 1965. This comprised of 41 pages with seven articles that had three research papers (the syndrome of tremors, mental regression and anemia; neonatal blood pressure recording; and effects of long acting sulfonamides), a review on tremors, a case series (diaphragmatic disorders), book reviews and current liter...

Infantile tremor syndrome: Role of Vitamin B12 revisited

OBJECTIVE To study the role of Vitamin B12 as an etiological factor in patients of infantile tremor syndrome (ITS). METHODS Twelve consecutive admissions of children diagnosed clinically as ITS were assessed. Assessment was done using a predefined pro forma to document patient demographic factors, general examination, systemic examination as well as relevant hematological and biochemical inve...

Modern Times